Distribution of protein kinase C isoforms after infection of macrophages with Leishmania major.
نویسندگان
چکیده
We characterized the effects of Leishmania infection on activation-induced translocation of protein kinase C (PKC) isoforms in murine bone marrow-derived macrophages. Although PKC-dependent gene expression was attenuated by infection, the distribution and translocation of PKC isoforms were unaffected. However, subsequent dissociation from membranes was substantially delayed for some isoforms, particularly PKCbeta.
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عنوان ژورنال:
- Infection and immunity
دوره 66 4 شماره
صفحات -
تاریخ انتشار 1998